The seven-pass transmembrane cadherin Flamingo controls dendritic self-avoidance via its binding to a LIM domain protein, Espinas, in Drosophila sensory neurons

摘要

Members of the Flamingo cadherin family are required in a number of different in vivo contexts of neural development, including growth control of dendrites, axonal navigation, tract formation, and target selection. The authors demonstrate that Esn binds to the carboxyl cytoplasmic tail (C-tail) of Fmi and that this binding was critical for dendritic self-avoidance.